Urobilinogen is a medical test of urine where it measures the level of urobilinogen in a urine test. Today in this topic we are discussing the urobilinogen in urine that what is level of urobilinogen in urine and what causes this symptom, with different tests we can easily identify this test and how can we get the best treatment to recover urobilinogen in Urine.
Before we start the Levels, Causes, Tests, Treatment of urobilinogen in Urine, we must understand that what is urobilinogen?
A Brief Explanation of Urobilinogen in Urine:
Urobilinogen is one of the indicators for the metabolism of Bilirubin and it is measured in urine, urobilinogen is formed in the intestine by the effect of bacteria which convert the direct bilirubin excreted from the bile duct into urobilinogen. So it is the part of bile pigment that is formed in the intestinal tract and excreted in urine.
What does that mean Urobilinogen?
As we know now that Urobilinogen is a colorless part if bilirubin reduction which is formed in the intestines by bacterial action.
Causes of Abnormal Urobilinogen
We will be discussing what bilirubin is and how it is the part of Urobilinogen?
These are the simple point which will give you the idea that how this disease appeared in the human body.
As we all know that any type of internal disease mostly affects the liver and interrupt its function to operate which affects every close part of the digestive system. So we will be discussing the bilirubin Metabolism in the liver and the diseases related to this part of the body.
- First of all, it starts with the parasite which is the main functions of the liver.
- The inderthelien lining of the liver sinusoid: remember the inderthelien is a type of cell that makes up blood vessel walls but the wall of the sinusoid is more pores.
- This way they allowed more protein such as endothelium to pass through the vessel walls.
- Bilirubin is entered into the liver attached to the albumin.
- The albumin travels through the sinusoid and impasses into the space of disuse.
- once in a space of disuse the Albumin and the bilirubin disassociate and the bilirubin moves into the parricide by a bilirubin transporter.
- The bilirubin in a parricide then gets acted upon by UDP glucuronosyl Transferees.
- This attaches the glucuronic acid to bilirubin to produce bilirubin monoglucuronide.
- This bilirubin monoglucuronide intern can have another glucuronic acid attached to produced bilirubin Diglucuronide.
- Collectively Bilirubin mono and Dig, glucuronide are known as conjugated bilirubin.
- Now the conjugated bilirubin can be excreted into the boi-Canaliculi and this is done by a transporter called multi drag resistance associated protein tube which usually abbreviated to “MRP2”.
- In this way, conjugated bilirubin is excreted into the gut and the bilirubin pathway continuous.
What does it mean when someone had Urobilinogen in their Urine?
As per the Wikipedia and sources, we have found that in certain liver diseases, such as billiard obstruction or hepatitis. To excess bilirubin can build up in the blood and is elevated in urine.
The presence of bilirubin in urine is an early indicator of liver disease and can occur before clinical symptoms such as jaundice develop.
What are the hereditary diseases associated with failure of metabolism?
1# The first particularly nasty and rare diseases are called Cruder Najjan this is the results of a lack of major deficiency in UDP Gulcuronyl transferees.
2# this causes a build-up of unconjugated bilirubin in the blood which is toxic to the brain and causes Encephalopathy in newborns with this condition.
1# The next disease is called Gilbert and it causes a reduced activity of UDP Gulcuronyl transferees.
2# Usually this syndrome is as seem thematic, however during the period of increase thymolysis that is increase the red cell break down and jaundice can occur.
3# other than it’s a molajondus during this period gilbery’s is not found in any other symptom.
It is said that about five to ten percent of the total population has gilbery’s symptom. This may be it should be classified as a disease.
1# This disease is called Dubin Johnson syndrome, this is due to imputation to the MRP2 protein.
2# This means that conjugated bilirubin is not excreted into the bile and the Gut.
3# This causes a build up a conjugated bilirubin in the blood.
4# However the cause of conjugated bilirubin is not toxic like unconjugated bilirubin.
5# There is no symptom other than jaundice and treatment is usually not necessary.
This is the last disease called Rotor’s and this disease is the little bit of mystery
1# It seems similar to Dublin Johnson syndrome and causes an increase in conjugated bilirubin in the blood.
2# But it cause for this disease is not determined.
3# A Glutathione has the transference of its deficiency has been suggested as this is the transporter of bilirubin within the decide for now the cause is unknown.
Urobilinogen in Urine: Levels, Causes, Tests, Treatment
1# Levels of urobilinogen in Urine:
The Different type of Urobilinogen Levels in Urine has measured and shows the result as per the levels.
A#. Normal Urobilinogen Range In Urine
The ordinary urobilinogen range ought to be less than 17 mmol/l (< 1mg/dl). In the event that your specialist sees that it is higher or lower than the required range, at that point he will direct further tests.
B#. Urobilinogen measuring range
The estimating urobilinogen go is 0 – 8 mg/dl or can be anyplace between 0.2 mg/dL to 1.0 mg/dL.
C#. Abnormal urobilinogen levels
The adjustment in esteem might be low and high
2# Causes of urobilinogen in Urine:
A#. Causes in the High Values
- inordinate breakdown of red platelets
- overburdening of liver
- Overabundance urobilinogen generation
- Overabundance hematoma (re-assimilation)
- Liver cirrhosis
- Hepatic contamination
- harming of liver
B#. Causes in the Low Values
- stopped up bile entry
- Disappointment underway of bile
3# Tests and Treatment of urobilinogen in Urine:
There are different test strips accessible in the medical field. The pieces of P-dimethylamino benzaldehyde are dunked into an example of pee and the outcomes are then analyzed. The strips will turn pink if there is an adjustment in the levels of urobilinogen in your pee. If not, it will continue as before.
On the off chance that the test is sure, additionally, tests ought to be done to check in the event that you have enough platelet creation in your body. On account of a predominant ailment, the specialist distinguishes it and treats it before it influences the liver any further.
Urobilinogen normally present in urine and the presence of the normal level of urobilinogen in urine indicate normal bilirubin metabolism.
However, increase the level of urobilinogen in urine indicates hemolytic jaundice or indicate increased the excretion of bilirubin in the intestinal tract. So, the increase urobilinogen in urine indicates hemolytic jaundice.
Urobilinogen may be absent in urine, the absence of urobilinogen from urine indicate obstructive jaundice, the obstruction of the main bile duct, which prevents the excretion of bile pigment in the intestinal tract. So there is no urobilinogen will be formed and no urobilinogen will be excreted in urine.